Fabrication of large diameter spheres by the ardeform process final report

Fabrication of large diameter spherical pressure vessels by stretch forming at cryogenic temperature

POOL File Catalog, Collection and Metadata Components

The POOL project is the common persistency framework for the LHC experiments to store petabytes of experiment data and metadata in a distributed and grid enabled way. POOL is a hybrid event store consisting of a data streaming layer and a relational layer. This paper describes the design of file catalog, collection and metadata components which are not part of the data streaming layer of POOL and outlines how POOL aims to provide transparent and efficient data access for a wide range of environments and use cases - ranging from a large production site down to a single disconnected laptops. The file catalog is the central POOL component translating logical data references to physical data files in a grid environment. POOL collections with their associated metadata provide an abstract way of accessing experiment data via their logical grouping into sets of related data objects.Comment: Talk from the 2003 Computing in High Energy and Nuclear Physics (CHEP03), La Jolla, Ca, USA, March 2003, 4 pages, 1 eps figure, PSN MOKT00

Aspects of large-scale chromatin structures in mouse liver nuclei can be predicted from the DNA sequence

The large amount of non-coding DNA present in mammalian genomes suggests that some of it may play a structural or functional role. We provide evidence that it is possible to predict computationally, from the DNA sequence, loci in mouse liver nuclei that possess distinctive nucleosome arrays. We tested the hypothesis that a 100 kb region of DNA possessing a strong, in-phase, dinucleosome period oscillation in the motif period-10 non-T, A/T, G, should generate a nucleosome array with a nucleosome repeat that is one-half of the dinucleosome oscillation period value, as computed by Fourier analysis of the sequence. Ten loci with short repeats, that would be readily distinguishable from the pervasive bulk repeat, were predicted computationally and then tested experimentally. We estimated experimentally that less than 20% of the chromatin in mouse liver nuclei has a nucleosome repeat length that is 15 bp, or more, shorter than the bulk repeat value of 195 ± bp. All 10 computational predictions were confirmed experimentally with high statistical significance. Nucleosome repeats as short as 172 ± 5 bp were observed for the first time in mouse liver chromatin. These findings may be useful for identifying distinctive chromatin structures computationally from the DNA sequence

Long-range oscillation in a periodic DNA sequence motif may influence nucleosome array formation

We have experimentally examined the characteristics of nucleosome array formation in different regions of mouse liver chromatin, and have computationally analyzed the corresponding genomic DNA sequences. We have shown that the mouse adenosine deaminase (MADA) gene locus is packaged into an exceptionally regular nucleosome array with a shortened repeat, consistent with our computational prediction based on the DNA sequence. A survey of the mouse genome indicates that <10% of 70 kb windows possess a nucleosome-ordering signal, consisting of regular long-range oscillations in the period-10 triplet motif non-T, A/T, G (VWG), which is as strong as the signal in the MADA locus. A strong signal in the center of this locus, confirmed by in vitro chromatin assembly experiments, appears to cooperate with weaker, in-phase signals throughout the locus. In contrast, the mouse odorant receptor (MOR) locus, which lacks locus-wide signals, was representative of ∼40% of the mouse genomic DNA surveyed. Within this locus, nucleosome arrays were similar to those of bulk chromatin. Genomic DNA sequences which were computationally similar to MADA or MOR resulted in MADA- or MOR-like nucleosome ladders experimentally. Overall, we provide evidence that computationally predictable information in the DNA sequence may affect nucleosome array formation in animal tissue

Mit Links in den Shareholder-Kapitalismus?

Wer verpflichtet die Aktiengesellschaften? Und wem sind sie verpflichtet? In nahezu allen westlichen Industrieländern werden derzeit die Rechte der Hauptversammlungen und Aufsichtsorgane gestärkt, Übernahmen erleichtert, Minderheitsaktionäre besser geschützt und Auflagen zur Transparenz verschärft. Warum aber machen sich gerade sozialdemokratische Parteien für diese aktionärsorientierten Reformen stark

A stacked ensemble learning and non-homogeneous hidden Markov model for daily precipitation downscaling and projection

Global circulation models (GCMs) are routinely used to project future climate conditions worldwide, such as temperature and precipitation. However, inputs with a finer resolution are required to drive impact-related models at local scales. The nonhomogeneous hidden Markov model (NHMM) is a widely used algorithm for the precipitation statistical downscaling for GCMs. To improve the accuracy of the traditional NHMM in reproducing spatiotemporal precipitation features of specific geographic sites, especially extreme precipitation, we developed a new precipitation downscaling framework. This hierarchical model includes two levels: (1) establishing an ensemble learning model to predict the occurrence probabilities for different levels of daily precipitation aggregated at multiple sites and (2) constructing a NHMM downscaling scheme of daily amount at the scale of a single rain gauge using the outputs of ensemble learning model as predictors. As the results obtained for the case study in the central-eastern China (CEC), show that our downscaling model is highly efficient and performs better than the NHMM in simulating precipitation variability and extreme precipitation. Finally, our projections indicate that CEC may experience increased precipitation in the future. Compared with around 26 years (1990–2015), the extreme precipitation frequency and amount would significantly increase by 21.9%– 48.1% and 12.3%–38.3%, respectively, by the late century (2075–2100) under the Shared Socioeconomic Pathway 585 climate scenario

The evolution of mass loaded supernova remnants: II. Temperature dependent mass injection rates

We investigate the evolution of spherically symmetric supernova remnants in which mass loading takes place due to conductively driven evaporation of embedded clouds. Numerical simulations reveal significant differences between the evolution of conductively mass loaded and the ablatively mass loaded remnants studied in Paper I. A main difference is the way in which conductive mass loading is extinguished at fairly early times, once the interior temperature of the remnant falls below ~ 107 K. Thus, at late times remnants that ablatively mass load are dominated by loaded mass and thermal energy, while those that conductively mass load are dominated by swept-up mass and kinetic energy. Simple approximations to the remnant evolution, complementary to those in Paper I, are given

Desempenho e características de carcaça de bovinos F1 Pardo Suiço corte x Nelore, inteiros ou castrados em diferentes idades.

Foram avaliados o desempenho e as características de carcaça de 104 bovinos F1 pardo suíço corte x nelore, distribuídos, a partir do nascimento, em cinco tratamentos: castração ao nascimento, castração ao desmame, castração aos doze meses, castração aos dezoito meses e não castrados . Os animais foram criados em pastagens (perenes) cultivadas, com suplementação na primeira seca e terminação em confinamento na segunda seca. O ponto de abate foi estipulado para um mínimo de 460 quilos de peso vivo e 3 milímetros de gordura de cobertura, sendo esta medida por ultra-sonografia. Não houve diferenças entre os tratamentos (P>0,05) para ganho diário e peso vivo do nascimento aos dezoito meses de idade e durante o período de engorda em confinamento. Entretanto, animais inteiros mostraram um melhor desempenho (P<0,05) do que os castrados no período de dezoito a vinte meses de idade. Não houve influencia (P<0,05) da idade de castração sobre as características de carcaça, mas animais castrados foram superiores (P<0,05) aos animais inteiros em termos de acabamento e proporção de traseiro. Por outro lado, os inteiros apresentaram melhor rendimento de carcaça (P<0,05) que os castrados, independente da época da castração.bitstream/item/104670/1/Desempenho-e-caracteristicas-de-carcaca.pd